Xue-wen Chen, Ph.D

 

Home     |     Awards     |     Teaching     |     Activities     |     Contact

 

 

Research Area

 

Software

 

Sponsors

 

Lab Members

 

Publications

 

ITTC

 

My research focuses on methods for machine learning, data mining, and their applications to bioinformatics, systems biology, and cancer research.

 

Machine Learning/Data Mining

  • Improving Bayesian network structure learning with mutual information-based node ordering in the K2 algorithm, IEEE Transactions on Knowledge and Data Engineering, 20(5), May 2008.               Abstract          Software
  • Minimum Reference Set Based Feature Selection for Small Sample Classifications. ICML¡¯07, 153 - 160, 2007. Link
  • Data-dependent Kernel Machines for Microarray Data Classification, IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB), 4:583, 2007. Link
  • Machine Learning and Its applications to Biology, PLoS Computational Biology, vol. 3(6), e116, 2007.    Link
  • Multi-class feature selection for texture classification. Pattern Recognition Letters, vol. 27(14), pp. 1685-1691, 2006. Link
  • Kernel-Based Distance Metric Learning for Microarray Data Classification. BMC Bioinformatics, 7:299, 2006. Link      Codes
  • SMO Based Pruning Method for Sparse Least Squares Support Vector Machines. IEEE Transactions on Neural Networks, vol. 16(6), pp. 1541-1546, 2005.      Link
  • Pruning Support Vectors for Imbalanced Data Classification. International Joint Conference on Neural Networks, vol. 3:1883-1888, 2005..
  • Feature reduction and morphological processing for hyperspectral image data. Applied Optics, vol. 43 (2), pp.1-10, 2004.
  • An Improved Branch and Bound Algorithm for Feature Selection. Pattern Recognition Letter, vol. 24(12), pp. 1925-1933, 2003. Link
  • Facial Expression Recognition: A Clustering-Based Approach. Pattern Recognition Letter, vol. 24 (9-10), pp. 1295-1302, 2003. Link
  • New training strategies for RBF neural networks for X-ray agricultural product inspection. Pattern Recognition, vol. 36(2), pp. 535-547, 2003.
  • Radial basis function neural networks for nonlinear Fisher discrimination and Neyman-Pearson classification. Neural Networks, vol. 16:529-535, 2003.

 

Biological Network Discovery

  • An effective structure learning method for constructing gene networks. Bioinformatics, 22(11):1367-1374, 2006.      Link
  • Prediction of Protein-protein Interactions Using Random Decision Forest Framework. Bioinformatics, 21(24): 4394-4400, 2005.             Link                  Website
  • Domain based predictive models for protein-protein interaction prediction. EURASIP Journal on Applied Signal Processing, special issue in Bioinformatics, vol. 2006, Article ID 32767, 2006.   Link
  • Large-scale protein-protein interaction prediction using novel kernel methods. International Journal of Data Mining and Bioinformatics (in press).

 

Protein Function Prediction

  • Protein function assignment through mining cross-species protein-protein interactions, PLoS ONE, 3(2): e1562, 2008.            Link      Software

 

Protein Binding Site Prediction

  • To be added

 

Biomarker Detection/Cancer Research

  • Data-dependent Kernel Machines for Microarray Data Classification, IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB), 4:583, 2007. Link
  • Bayesian Neural Network Approaches to Ovarian Cancer Identification from High-resolution Mass Spectrometry Data. Bioinformatics, 21 (suppl_1):i487-i494, 2005. Link
  • Ovarian Cancer Identification Based on Dimensionality Reduction for High-Throughput Mass Spectrometry Data. Bioinformatics, vol. 21(10), pp. 2200-2209, 2005.                     Link
  • Structural risk minimization based gene expression profiling analysis. International Journal on Bioinformatics Research and Applications, vol. 3(2), 153-169, 2007. Link
  • Margin based wrapper methods for gene identification using microarray. Neurocomputing, vol. 69 (16-18): 2236-2243, 2006. Link
  • Kernel-Based Distance Metric Learning for Microarray Data Classification. BMC Bioinformatics, 7:299, 2006. Link   Codes

 

 

 

Assistant Professor 

Electrical Engineering and Computer Science Department

The University of Kansas

Lawrence, KS

 

 

Ph.D. Carnegie Mellon University

Pittsburgh, PA