Development of an Integrated Bioinformatics Information Infrastructure
Project Award Date: 10-13-2004
The Army's chemical and biological defense research and development interests reflect numerous activities that should benefit significantly from the increased facility of data flow and hypothesis testing that arise from an enhanced informatics infrastructure. Chemical and biological defense research is multifaceted, involving issues from the sub-cellular level through ecological and geographic dynamics of a disease. The same is true of current life science research activities at the University of Kansas. Given the related nature of various of the KU efforts and those under way within Edgewood Chemical Biological Center (ECBC), it is logical to expect that bioinformatics infrastructure to be developed under this effort at KU in conjunction with local research activities should be relevant to, and readily extensible to, the information management needs within the ECBC.
ITTC researchers will develop system architecture to provide the computing; data storage, and networking capabilities that will compose a bioinformatics infrastructure to facilitate multi-faceted bioresearch efforts. The system architecture will support large-scale processing of heterogeneous data from diverse sources as well as sophisticated algorithms to extract meaningful information and suggest new experiments. This architecture must support the way biologists work, e.g., revision and redesign experiments based on results from previous experiments. Providing feedback to earlier stages of an experiment based on downstream data is important to improving the efficiency of biological investigations. Thus, work flow, information retrieval, data storage, processing, and networking issues will factor into the design. The system design will specify suitable data and compute servers. Collaborative environments will also be a component of the overall system architecture. The network to support the system will be specified. Collaborations and sharing of knowledge across all aspects of multi-faceted bioresearch endeavors will be greatly enhanced through the systematic design of the supporting information and computing systems.
Faculty Investigator(s): Victor Frost (PI), Terry Clark, Susan Gauch, Gary Minden
Student Investigator(s): Alexander Garrett, Lance Feagan, Justin Rohrer, Jesse Stanley, Keith Preston, Doug Herbers, Andrew Ozor, Justin Ward, Heather Amthauer
Primary Sponsor(s): U.S. Army